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showed that PT2385 selectively disrupts the heterodimerization of HIF-2α with ARNT, thereby inhibiting the transcription of downstream oncogenic targets such as VEGF, EPO, and cyclin D1
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Peptide 1920 demonstrated similar two-site binding affinity ( K D1 = 0.9 ± 0.5 µM, K D2 = 9.8 ± 6.9 µM) but less competitive inhibition ( K i = 25.0 ± 1.8 µM) than 1907, indicating that the additional residues do not significantly improve peptide activity
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